An optical study of alumina films thermal evolution upon ammonia annealing

The physical and structural evolution of alumina films deposited by ALCVD annealed at high temperatures in N₂ has been studied.Low temperature post deposition treatments in NH₃ (PDN) have been performed to evaluate the impact of nitrogen incorporation in the alumina film on its thermal stability. Thermal evolution has been studied by deep UV spectroscopic ellipsometry and grazing X-ray reflectance techniques. AFM measurements were also performed to confirm and complete the ellipsometric and GXR analysis.The change of the crystalline structure was detected by ellipsometry by the different UV refractive index, while the GXR provided a unique thickness evaluation.It was therefore possible to determine the layer densification after the thermal treatment and the impact of the PDN on the transition temperature.     

A new flow reactor for the treatment of polluted water with microwave and ultrasound

Microwave (MW) and high‐intensity ultrasound (US) provide innovative techniques for the degradation of persistent organic pollutants (POPs). When Fenton's reagent is used to treat industrial wastes, organic pollutants are degraded by highly reactive hydroxyl radicals (HO·) that can oxidize almost any organic compound to carbon dioxide and water. These reactions, when carried out under US or MW, are faster and much more efficient. The present work assesses the combined effect of US and MW using a new flow reactor developed in our laboratory. In this 5 L pilot reactor the liquid was pumped in parallel through a modified domestic MW oven and through a cell where it was irradiated with two US generators working at 20 and 300 kHz, while MW irradiation took place in a modified domestic oven. We studied the degradation of 2,4‐dibromophenol (0.1 g L^?1 in water) by Fenton's reagent, assessing the contribution of each energy source to the overall effect, and found that MW and US‐300 kHz played the main role. A modest amount of oxidant (6 mL 30% H₂O₂ per 1 L of polluted water) sufficed to achieve complete degradation within 6 h, at which time organic compounds were no longer detectable. Even if no Fenton's reagent was added, about one half of the pollutant was degraded after 3 h irradiation. Copyright © 2007 Society of Chemical Industry     

Path‐following algorithms and experiments for an unmanned surface vehicle

This paper addresses the problem of path following in two‐dimensional space for underactuated unmanned surface vehicles (USVs), defining a set of guidance laws at the kinematic level. The proposed nonlinear Lyapunov‐based control law yields convergence of the path‐following error coordinates to zero. Furthermore, the introduction of a virtual controlled degree of freedom for the target to be followed on the path removes singularity behaviors present in other guidance algorithms proposed in the literature. Some heuristic approaches are then proposed to face the problem of speed of advance adaptation based on path curvature measurement and steering action prediction. Finally a set of experimental results of all the proposed guidance laws, carried out with the Charlie USV, demonstrates the feasibility of the proposed approach and the performance improvements, in terms of precision in following the reference path and transient reduction, obtained by introducing speed adaptation heuristics. © 2009 Wiley Periodicals, Inc.     

Thermodynamic properties of amorphous silicon via tight binding simulations

An atomic-scale structure of amorphous silicon, generated by reverse Monte Carlo, has been used as a starting configuration for finite temperature molecular dynamics simulations performed by an orthogonal tight binding Hamiltonian. Structural, dynamic, elastic and electronic structure properties have been investigated in the range of temperatures up to and above the melting transition. The amorphous silicon structure undergoes a melting transition at a temperature sensibly smaller than that of the crystalline structure. Above this temperature, the structure has the same properties of an under-cooled liquid and it has a metallic behavior.     

Tunneling enhancement through a barrier surrounded by a mesoscopic cavity

We examine the conductance behavior of a cavity containing a relatively opaque transverse barrier. We show that the transmission of this structure is strongly dependent on the longitudinal position of the barrier and, in particular, has a maximum value when the barrier is located exactly in the middle of the cavity. In this specific condition the overall conductance is much greater than that associated with the barrier alone. Finally we propose a physical interpretation for the obtained numerical results.     

Kuwanon‐L as a New Allosteric HIV‐1 Integrase Inhibitor: Molecular Modeling and Biological Evaluation

HIV‐1 integrase (IN) active site inhibitors are the latest class of drugs approved for HIV treatment. The selection of IN strand‐transfer drug‐resistant HIV strains in patients supports the development of new agents that are active as allosteric IN inhibitors. Here, a docking‐based virtual screening has been applied to a small library of natural ligands to identify new allosteric IN inhibitors that target the sucrose binding pocket. From theoretical studies, kuwanon‐L emerged as the most promising binder and was thus selected for biological studies. Biochemical studies showed that kuwanon‐L is able to inhibit the HIV‐1 IN catalytic activity in the absence and in the presence of LEDGF/p75 protein, the IN dimerization, and the IN/LEDGF binding. Kuwanon‐L also inhibited HIV‐1 replication in cell cultures. Overall, docking and biochemical results suggest that kuwanon‐L binds to an allosteric binding pocket and can be considered an attractive lead for the development of new allosteric IN antiviral agents.     

Long-term human exposure to lead from different media and intake pathways

Lead (Pb) is well known as an environmental pollutant: it can accumulate in various media, so actual lead exposure reflects both historical and present contaminations. Two main challenges then emerge: obtaining updated information to gain an overall picture of the sources of exposure, and predicting the resulting internal body exposure levels and effects that occur under long-term exposure conditions. In this paper, a modeling approach is used to meet these challenges with reference to Danish exposure conditions. Levels of lead content in various media have been coupled with data for lead intake and absorption in the human body, for both children and adults. An age-dependent biokinetic model allows then for determination of the blood lead levels resulting from chronic exposure. The study shows that the actual intake of lead is up to 27% of the Provisional Tolerable Daily Intake (PTDI) for children and around 8% for adults. It is confirmed that the critical route of exposure is via ingestion, accounting for 99% of total lead intake, while inhalation contributes only to 1% of total lead intake. The resulting lead levels in the blood after 2 years of exposure to actual contamination conditions have been estimated as up to 2.2 μg/dl in children and almost 1 μg/dl in adults. Impacts from lead can occur even at such levels. The role of historical and present sources to lead in the environment is discussed, and, for specific child and adult exposure scenarios, external-internal concentration relationships for the direct linkage between lead in environmental media and resulting concentrations of lead in blood are then presented.     

Characterization of Low‐Molecular‐Weight PLA using HPLC

HPLC is applied and assessed as an effective tool to investigate both the production of PLA by polycondensation and its corresponding degradation. A new HPLC calibration procedure, through which it is possible to fully characterize LMW PLA samples by determining the concentration of each individual oligomer, is developed. A comparison between HPLC, ¹H NMR spectroscopy and non‐aqueous solution titration is also reported in order to confirm the reliability of the proposed method. Finally, the proposed analytical technique is applied to monitor the development of a polycondensation reaction performed at 150 °C and 133.3 mbar for 12 h.

     

Scratch Resistance Enhancement of Polymer Coatings

This review presents the state of the art regarding the improvement of scratch resistance of polymeric coatings. In particular, our attention is focused on the effect of inorganic nanometric fillers on the scratch resistance of organic coatings. Two main strategies are described for the achievement of such nanostructured hybrid organic/inorganic coatings: either a top‐down or a bottom‐up approach.